Four Franciscans belonged to the group of twelve clergy that took part in the second crossing of the Atlantic by Admiral Christopher Columbus in the fall of 1493. From 1500 onward the Franciscans remained on Santo Domingo. They were engaged in the Caribbean, and even more in Mexico, in the spreading of the Gospel message among the survivors of the Spanish conquest. They were represented by brothers such as Peter of Gent, Toribio of Benaventure, Bernadine of Sahagún and Jacob the Dane. This presentation will offer an overview of the work of the fifteen Franciscan provinces that were founded from 1505 to 1612 in North, Central, and South America.